Taubes isn't taken seriously by most dieticians and nutrition researchers we talk to (I work at a nutrition startup).

I'd say that if there is any value to Taubes, it is this:

Different foods, given the same calories, will fill you up or nourish you at varying degrees.

300 calories of oreo cookies isn't the same as eating a banana and some chicken.

The main practical benefit people get from low carb, paleo, etc is that they're eating less sugar and junk, and thus eating healthy food with better overall satiety. As a result, they lose weight because they're eating fewer calories.

You can lose weight eating twinkies, it's just hard to do because it's bad for your health, not nutritious, and leaves you feeling hungry because it's all carbs.

A more scientific and less paleo-obsessed way to think about carbohydrates is this:

Carbs are fuel, if you're an athlete, you have a use for them. If you live a sedentary lifestyle, excess fuel isn't going to do you any favors.

Adjust accordingly.

In the end: calories in, calories out. Humanity hasn't defeated the laws of thermodynamics. It's just a question of how easy and healthy it is to maintain a sub-maintenance caloric intake.

Edit:

Okay people, I just got done saying low carb made sense if you weren't an athlete, what exactly are you arguing against? I agree with you guys, I just think the reasoning and rationale should be taken in the context of current nutrition research and not some demagogue's book that is obsessed with a dietary aesthetic rather than data.

Semmelweis is a favorite "management science" topic; there's even a pop-psych phenomenon called the "Semmelweis Reflex"; the Wikipedia article on it recapitulates much of what Aaron wrote here. The Gladwell formula of using Semmelweis' personal narrative to articulate a frailty of human reasoning was employed to great effect in Ayres _Super Crunchers_; the Semmelweis section is, for instance, noted prominently in the NYT book review.

Aaron has oversimplified the Semmelweis story in some material ways:

* Semmelweis didn't institute "handwashing" in Vienna hospitals. Contrary to the conventional wisdom, which suggests that doctors in the 1840s were sticking horse-manure-covered hands into the exposed wounds of patients, handwashing was apparently already a norm. What Semmelweis did differently was to use lime to wash hands.

* Semmelweis' actual theory of the cause of childbed fever was wrong, and it was wrong in ways that made his recommendations hard to take seriously. Semmelweis' contention was that "cadaveric particles" were making their way into patients, and that those particles could only be removed by lime. But doctors observed cases in which no contact with either cadavers or injected or symptomatic patients lead to the same cluster of illnesses. It was thus difficult for Semmelweis to make a "scientific" case for why the lime worked; it obviously didn't help that he was wrong about why it did (his work predates the germ theory of disease, which would have taught him that rather than lime being effective at removing specific particles, it was instead effective at killing bacteria).

* Aaron's story (and Ayre's) has a heroic Semmelweis pleading for doctors to simply wash their hands in a specific way to save lives. But that's not necessarily what Semmelweis was arguing. Instead, the case he could have been making, loudly, was for an actual, specific, incorrect cause of childbed fever.

* Semmelweis himself was, apparently long before he lost his post, a notorious asshole. It did not help his cause that instead of carefully reasoning about the actual evidence, he instead seized on a single explanatory theory of childbed fever and then demanded (often by barging into hospital wards and berating the staff) that his peers adhere to it.

The point is not that Semmelweis didn't make an important discovery, or that we shouldn't be mindful of warped-sounding new knowledge that contradicts our existing theories. Of course we should be objective when considering facts that threaten our existing theories. But there's a reason John Snow and Joseph Lister [and Pasteur] are better known in the development of the germ theory of disease, and there's more to learn from the Semmelweis story than how the audience to a new theory should behave.

"Severities should be dealt out all at once, so that their suddenness may give less offense; benefits ought to be handed ought drop by drop, so that they may be relished the more." - Niccolo Machiavelli