Which psychedelics (shrooms, acid, peyote, salvia, ketamine, ayahuasca) would be best for endogenous, treatment-resistant depression? If there are any with a proven effect, do they have to be taken periodically?
I'd love to read your story. Did you write about it? The years of depression, traveling to the ayahuasca place, the sessions, the changes you made in your life afterwards.
Ketamine is not generally considered a psychedelic. It's a disassociative.
I don't think I've ever seen a study comparing this in the way you describe, but from piecing together other papers I recall seeing I would say probably psiloc(yb)in, possibly DMT ("ayahuasca"), with LSD and mescaline (peyote/san pedro) being qualitatively similar. All of these are primarily serotonergic.
I'd be surprised if Salvia does jack shit in that domain, regardless of how trippy the experience can be. It acts very differently.
kinda splitting hairs, but these words do have specific meanings. psychedelics and dissociatives of hallucinogens, a broader category of drugs. you definitely see weird stuff if you take enough ketamine, but the hallucinations have a very different character.
subjectively, I find psychedelics to have more of an "organic" feel and dissociatives to have a more "synthetic" feel, although I imagine others might describe it differently.
It can absolutely induce psychedelic experiences - in medical literature it's not generally (though this is not entirely consistent) classified as a psychedelic.
(Speaking for tryptamines as I’m not to sure about the others). It might require periodic doses until you actually resolve your trauma, which more often than not takes a lot of uncomfortable digging. It’s typical to spend at least a couple of weeks at an ayahuasca retreat, drinking several times throughout the stay. In my experience, unless you’re somewhat lucky, won’t have that life changing experience on your first session.
I made a huge mistake of not applying there and to MIT. I was concerned about the heat in Pasadena and the piles of snow in Boston (silly me. why don't Ivy's relocate someplace nice like Hawaii?). I aced the math SAT-I section without studying and was in GATE and NMS. Instead, I went to a top 50 public state research uni (that became a party school just as I got there) because it was a sure thing. I think I learned more and developed more initiative because it was so sink-or-swim, and the standards were high and the assistance was low. I even hustled an undergrad paid research gig in a top security lab to fix grad students' and postdocs' network code that looked like spaghetti after being puréed in a blender.
> I made a huge mistake of not applying there and to MIT. I was concerned about the heat in Pasadena and the piles of snow in Boston (silly me. why don't Ivy's relocate someplace nice like Hawaii?).
> I was concerned about the heat in Pasadena and the piles of snow in Boston
As a native Californian living in Pasadena, I also hate the heat -- but, unlike Boston (in my experience), air conditioning is standard, and makes the outside situation matter far less. (It's also not usually that bad, and it's almost always a dry heat.)
The one time I visited Boston (for an undergraduate research program), it was frosty the first few days, and then hellishly humid every day thereafter. The dorm I was staying in didn't really have temperature control, and I got the sense that AC wasn't as common.
It's not even that hot in Pasadena. Like, it gets warm in the summer, you may want to stay inside and turn on the AC, but it's typical southern California weather…
Thin article without much substance. Maybe rtPCR and more ELISA tests would put it to bed. But really, who cares? Musk does whine a lot and proclaim statements insouciantly without knowledge or expertise.
In other news, US cases are growing concave-up with no end in sight.
I just left CA after 42 years. Austin, apart from panhandling and corporate retail dominating commercial real estate, is awesome. Free tattoos line around the block for Friday the 13th on 6th st. was hilarious. People are much nicer and more social. Groceries are cheaper (HEB rocks). Traffic sorta sucks but it's nothing like LA or Bay Area commute. The weather is baller as long as it's not summer, in which case, vaca in Canada or Santa Cruz. Land outside of city limits is dirt cheap for whatever purpose, homestead or commercial. Property taxes are nearly 2%/yr in most of TX so there's a disincentive to owning expensive homes for most people.
People in CA aren't dating or having kids like TX, middle states, and UT. The coasts are graveyards for all but the rich, retirees, and high-income visiting employees; everyone else is like a SF "gold rush miner" trying to hang-on to a delusion, spending most of their income on rent. Screw that; build a life somewhere sustainable such as on the outskirts of a burgeoning city.
Nah man it isn’t life unless it’s summer in Austin. Back in my youth I would still bike everywhere, I would just plan my bike route to hit every public pool possible, like the main character in John Cheever’s ‘The Swimmer.’ And then I would eat some amazing Tex mex on a patio and then hit the springs for a night swim. Of course, nobody is doing that kind of thing these days anyways. I miss Austin. I miss my youth.
Pools. Heh. Had an in-ground one growing up and almost never used it. I had to do the chemicals, skim leaves, roll the solar cover, and change the diatomaceous earth. Everyone on the block had one too, and they were rarely used either.
Humidity kills me. For example, I had a Colombian gf but the weather in Barranquilla is mass murder.
Around the south Bay Area, I biked around the hills of the Almaden Valley and Mt. Umunhum incessantly, and skateboarded around the neighborhood until my knees had divots and layers of scars. Went to UC Davis where biking was de rigueur. Did some biking in Netherlands and Belgium, the former being a biking paradise.
The cis females in Austin are just my speed. Sadly, they don't have a chance. And, being a big city, the open-minded types I prefer are more abundant. One area I miss is SF's Castro where mixed gender bars facilitate hooking-up with cis females, but I'll be back. I don't miss SF's parking situation and am looking for cheaper ways to park near downtown Austin.
Folks seem friendlier in Austin than CA where almost everyone has a chip on their shoulder, is seething with dissatisfaction, and doesn't want to be sociable. Heck, I don't even mind chatting with the saner homeless people that aren't panhandling me. I met some very cool homeless people with interesting lives in Palo Alto, CA when Happy Donuts was the hangout.
What a horrible, drive-by comment. Why barf on someone else's birthday cake adapting to economic conditions? I suggest you try living in the Bay Area or LA, work an average job, and then talk about sustainability. There are plenty of satellite areas to live around Austin where houses are in the 300-400k range.
Thanks, I already did 20 years ago but I'm vegetarian. My mom's family is from north TX and my folks met in San Anton. Earth Burger in San Marcos is crazy good but 2-3x more expensive than regular fast food.
Isn't TikTok just Vine or beme redux? ADD-like dopamine- engagement addiction via short video content?
Do we really need more time-suck, content consumption platforms when people are lonelier, more atomized, unwilling/unable to socialize IRL, and divided from each other than ever?
I think there ought to be a two month annual holiday where social media is shutdown to encourage people to go outside and socialize because it won't happen otherwise.
Yes, it's LEGO for anyone with domain knowledge bias.
I would go one further: building a functional, prototype core vs. a marketable core are entirely different beasts given the litany of testing and customer considerations. It's difficult to say what exactly this kid did since the article is light on detail; it could be an achievement.
It's quite trivial to build a simple processor in HDL (.v or .vhdl) because the compiler synthesizes the actual digital logic for you. It's not much different than C or a functional language like Haskell or OCaml, but with considerations of timing and don't cares/high impedance.
PS: s/no more hard/no more difficult/ because "more hard" is always improper when "harder" exists.
