I used it on my Thinkpad x220 and NUC 5th gen (BOXD54250WYKH) and it worked great. https://www.qubes-os.org/hcl/ - The HCL is pretty decent actually. But since they have to work on older Linux Kernel and Xen releases for stability/security and the hardware needs to have VT-d, TPM, HVM/VMX etc enabled - they will always be lagging in terms of the newer hardware they can support.

Might want to try out the BOXD54250WYKH1 NUC - Amazon is still selling it.