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> I think marketingwise the vaccine will have a very, very hard time against PrEP

Probably not. PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?).

Of course this vaccine is just entering trials. We have no idea how effective it is, or what the side effects might be. As such we can only guess and hope that it is better than PrEP - though that is a somewhat low bar.



To be clear, Truvada (or Descovy) for vast majority of people will have essentially no side effects. There is a small increase in chance of kidney disease, mainly for those with other risk factors, the risk profile is similar to over the counter ibuprofen.

"HIV-positive individuals who use Truvada to control their infection are more likely to experience kidney damage and bone density loss than those who take it to prevent HIV infection, as so-called pre-exposure prophylaxis (PrEP)[2]. But “no significant health effects have been seen in people who are HIV-negative and have taken PrEP for up to 5 years,” according to the U.S. Department of Health and Human Services. Numerous studies have shown that the risk of HIV-negative Truvada users developing kidney disease is not statistically significantly different from those taking placebo[3]."

https://healthfeedback.org/claimreview/hiv-drug-truvada-link...


> PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?).

Please don’t spread this FUD. The side effects are rare and reversible by stopping the medicine. The checks are also required to check for other STIs.


That doesn't mean they are not nasty or don't need be checked for. Better than HIV/AIDS for sure, but common enough that a vaccine could be better.




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