I run a 1x10, and there is no problem with chain crossing. The 10/11/12 speed cassettes are basically not any wider than the regular 9 speed ones, so there is no more chain crossing than what you get for the middle ring on a 3x9. The optimization is all in narrower chains and sprockets.
That being said, I do run an upper chain guide to reduce probability of the chain falling off the chainring when the rear derailleur gets clogged with mud etc.