Are Netflix's streaming videos DRM'd? On a closed system like the PS3, an HTML5 video player might be possible, but how would they protect their video in a HTML5 video player on a desktop computer? DRM'd desktop video seems like a good opportunity for Flash and Silverlight since HTML5 is unlikely to offer might DRM support.
Just because your app is HTML5 doesn't mean you have to run it in a browser. Just like on phones, drop a WebView in and you're set. IIRC, Spotify actually uses Chromium in some capacity on their native client.