One reason why Prohibition didn't work (and why alcohol has been culturally significant for so long) is that alcoholic beverages are ridiculously easy to make. If you have fruit or grain, a container, and some time...
Attempting to regulate alcohol, as you note, is a fool’s errand.
Regulation isn’t the answer. It will take centuries of messaging and a shift in consumption patterns before it’s not profitable to commercially produce. Possibly.