I switched to AdGuard because uBlock Origin doesn't work with older versions of Safari (<13). It works pretty well on desktop and mobile. I like the ux (simple, but customisable if I need to tweak things).
I use Chrome only for work-related stuff and for compatibility tests (I don't want to contribute turning Chrome into another IE^2). I use uBlock Origin with Chromium-based browsers.
But anyone here use their Ad-blocker? Why I should consider it over uBlock Origin?