Many work 100% a few may have cosmetic quirks on their UI but remain usable, a few don't work at all, but those are a small number. Take a look at Yabridge, as suggested by another user, it's great. A nice aspect of running plugins under Yabridge/WINE is that you can run obsolete plugins that wouldn't load anymore on modern Windows versions, so there's no planned obsolescence that would stop you from using that beloved synth or effect that was never upgraded for example beyond Windows XP. The only problem I encountered with some among really old plugins, and I mean from well over 20 years ago, is that the installer stops as it detects a negative amount of storage available, which is very likely the result of trying to fit a bigger variable carrying the number of bytes free of modern filesystems structures into the smaller one that old code can read. I believe the error could be prevented through a quick & dirty kludge by implementing a WINE executable option that fakes the free storage the installer sees just temporarily until the end of the install procedure.