You wall off the non-falsifiable stuff in a box labeled "not science" and focus on the stuff that is falsifiable.
That is not necessarily a bad thing.
It's something that human consciousness seemingly has to do.
Science doesn't care about which ones you pick. You can be doing science with any set of initial non-falsifiable assumptions that humans are capable of holding.
You wall off the non-falsifiable stuff in a box labeled "not science" and focus on the stuff that is falsifiable.