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So how would you go about learning LC-MS/MS and applying the various separation techniques to small molecules or proteins?

Instruments start at 250k and many in universities are decades older than what is currently used in industry. For small molecules, the most challenging (and exciting) library's of compounds are owned by third parties.

It is my opinion that science, much like programming, one has to do it to learn it. There are limitations to the knowledge you gain without being hands on. See E.O Wilsons musings of the impact his formative years and post grad school wanderings in the south pacific. He is certainly a scientist but much of his knowledge and insight is due to the hands on approach he used to to gain that knowledge.



Completely agree. I don't think I am going to put a 900 MHz NMR or an Orbitrap in my basement :)


I know! I can just hear my daughter, 'Daddy, turn that down. I'm trying to watch Doc McStuffins. Why do you have to do science on a Saturday morning?'

Then there is the electrical bill and I already get hell from my wife for the water bill during the summer months.




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