Hand crafted textures are fine but so’s spending a chunk of time roughly equivalent to hand painting a few models and being able to have any arbitrary geometry rendered in a painterly fashion. You could even figure out a way to combine them, so that the computer can half-ass the parts a master painter would let apprentices handle, and then go back in and do the important parts by hand; I work in Illustrator and figuring out how to make it do half-assed, highly stylized lighting on arbitrary shapes I draw, then doing the rest myself, has been a lot of fun.