I think I've read about a quarter of the list, and only a couple of the ones I've read fit that title to me. I wish the list contained a line explaining why...
It's hard, but I think not impossible. I was thinking mostly in terms of explaining to people who have already read the book why people believe it belongs there.
E.g. I love all of Douglas Adams' books, but I have no idea what they're doing on this list.
A non-spoilery hint at which concept in those books someone thought was a mindfuck, would be nice.