House sends off one of his minions who find the brake cleaner in the sink cupboard, from which he immediately figures out that the patient's erratic behavior stems from a disease of the liver so the previous brain surgery was largely unneccesary.

It's never lupus.

It's a medical take on Sherlock Holmes. Everything makes more sense when viewed through that lens.

House and Wilson Holmes and Watson

Which is a criminological take on a medical doctor: https://en.wikipedia.org/wiki/Joseph_Bell

Yup; it isn’t a realistic show, but entertaining.