It's a TSOP48 package, I guess you could clamp it but not that easily. The bigger problem I see is that if you try to program it in-system, you need to apply power to it, and since the power rail is shared with the CPU, the CPU will wake up and try to read the chip, messing with the programming.
I wrote up my impressions for the Register:
https://www.theregister.com/2026/02/11/last_z80_machine/
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