Of course. It is a general purpose programming language, which allows deploying JavaScript code as CommonJS or AMD modules. It provides fairly rich type definitions.

I realize you are trying to say I am comparing apples to oranges, but the site explicitly mentions Human Javascript approach as inspiration, and Human Javascript is all about choosing your tools. I am pointing out that there is an incredibly powerful tool that works extremely well for large-scale software development.

There are probably good use cases for Ampersand.js. The argument in this article is a really mediocre at best use case.